ProFAT - Protein Functional Annotation Tool

Bradshaw C. R., Surendranath V., and Habermann B. BMC Bioinformatics 2006, 7:466 Link

ProFAT is a tool for the functional annotation of proteins via the detection of weak homologies. Sequence homology is detected with NCBI's PSI-BLAST system. Structural homology is detected with UCL's Threader software. These results are then combined by the use of GenBank annotation and basic text mining.

ProFAT requires the user to submit a keyword list along with the protein sequence. Several pre-made keyword lists are available, however, the system is used optimially with a user defined keyword list consisting of suspected or experimentally determined information.

Disclaimer: Since Threader 3.5 is for academic use only, Threader3.5 and HMMerThread will not be invoked in the case of commercial use.

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Enter the sequence below :	Keyword lists User Defined Keyword List Preprocess Keywords Case Sensitive Select pre-made Keyword List View & Select
ProFAT Core Modules Annotation Engine (PSI-BLAST with subsequent keyword mining) Threading (Threader3.5-based threading with subsequent keyword mining)	Modules for Domain Prediction Domain Prediction (RPS-BLAST and keyword annotation) HMMer for HMMerThread (HMM-based domain prediction; HMMerThread analysis only)
Advanced Options PSI-BLAST Iterations Domain Prediction Hits Threading Hits depth RPS-BLAST Threshold HMMer Threshold HMMerThread Extension	Powered by

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